Moon Path to Elsweyr is the #1 recommended mod for Skyrim! It adds the province of Elsweyr and new monsters, npcs, quest, etc.
The Mod has some custom enemies, foremost the Jungle Queen a Giant spider that's an ambush predator. They are quite powerfull and a lvl of higher than 10 is advised.
Also the Incursion Quest will lead you against a Thalmor expedition, these are large group of Thalmor. If you where able to survive the Thalmor Embassy in SKyrim you should be fine.
In the desert area you will find some tough Hyena's
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